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September 2022

Œstrogen Antagonisms: 19-Norprogesterone and 18 19-Dinortestosterone as Œstrone Antagonists

Journal/Book: (Reprinted from Nature Vol. 190 No. 4773 p. 353 only April 22 1961). 1961;

Abstract: Division of Biological Research G. D. Searle and Co. Chicago Illinois. CLEAVAGE of the angular methyl group at carbon-10 of the testosterone molecule rosults in a compound that is much mors potent than the parent as an œstrogen antagonist (unpublished work) and myotropic agent but not as an androgen. Since 19-norprogesterone has been known as a potent progestational agent for some years and 18 19-dinortestosterone has recently been synthesized by Dr. W. F. Johns of the Division of Chemical Research G. D. Searle and Co. these two materiale have been examined as antagonists of œstrone-induced vaginal smear changes in spayed mice. . . .

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