STUDIES ON THE MECHANISM OF BICARBONATE REABSORPTION IN MAN

Journal/Book: Reprinted from THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE St. Louis Vol. 56 No. 2 Pages 294-302 August 1960. 1960;

Abstract: GEORGE B. GORDON M.D. ALFRED EICHENHOLZ M.D. FRANK M. MACDONALD M.D. and THOMAS T. SEMBA M.D. Minneapolis Minn. From the Medical Radioisotope and Pathology Services. Veterans Administration Hospital. and the University of Minnesota Medical School SUMMARY AND CONCLUSIONS 1. In acute experiments intravenous infusions of large amounts of acetazolamide resulted in an average inhibition of bicarbonate reabsorption of approximately 40 per cent. Bicarbonate excretion not dependent upon carbonic anhydrase inhibition did not account for more than 10 per cent of that excreted. 2. Acetazolamide infusion resulted in an average inhibition of inorganic phosphorus reabsorption of approximately 26 per cent. This was found to be independent of decrease in glomerular filtration rate or increase in urine volume which were uniformly produced by the drug in the doses used. 3. The data are consistent with the hypothesis that bicarbonate reabsorption is dependent upon ion exchange but that reabsorption also occurs along a pathway shared in common with inorganic phosphorus. ___MH

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