A HYPERSENSITIVITY PHENOMENON PRODUCED BY STRESS: THE "NEGATIVE PHASE" REACTION

Journal/Book: AMERICAN JOURNAL OF CLINICAL PATHOLOGY Vol. 34 No. 1. July 1960 pp. 1-8 Printed in U.S.A.. 1960;

Abstract: Georgetown University School of Medicine Washington D. C. The role of Stress in disease has been a source of controversy and interest since Selye8 9 first published his unprecedented observations an the general adaptation syndrome. Since that time an extensive literature has accumulated an the effects of prolonged stress an the pituitary-adrenal axis; however the effects of a single brief episode of stress has received little attention. The stresses of life are most commonly short and intermittent. It therefore seemed of great interest to assess the effects of a single brief stress episode an adrenal-cortical function. These studies were stimulated by a surprising finding during the course of investigations an Alarmine a substance discovered by Geschickter and associates3 to produce lesions simulating those of the collagen diseases. . . .

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