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August 2021

THE INTERACTION OF QUATERNARY AMMONIUM COMPOUNDS WITH CHONDROITIN SULFATE

Journal/Book: Reprinted from Biochim. Biophys. Acta. Vol. 44 (1960) 577-585. 1960;

Abstract: Departments of Neurology and Biochemistry and Institute of Cancer Research College of Physicians and Surgeons Columbia University New York N. Y. (U.S.A.) SUMMARY The interaction of a series of mono- and di-quaternary ammonium compounds with chondroitin sulfate A has been studied. Quantitative precipitation of the polysaccharide occurs with cetyl pyridinium chloride and d-tubocurarine. The ratio moles quaternary bound/mole repeating unit of polysaccharide is 2 for CPC and I for curare. Evidence is presented to show that the rigid curare molecule precipitates by combining simultaneously with both the carboxyl and sulfate groups of the repeating unit of ChSA rather than causing inter-molecular aggregation. Di-quaternary compounds which do not have a rigid structure fail to precipitate chondroitin sulfate and show only weak interactions in solution. . . .


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