ALTERATIONS IN RESPIRATORY FUNCTION DURING NATURAL SLEEP

Journal/Book: Reprinted from THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE St. Louis Vol. 54 No. 2 Pages 216-222 August 1959. 1959;

Abstract: Durham N. C. From the Department of Medicine (Neurology and Pulmonary Divisions) Duke University Medical Center and the Veterans Administration Hospital Supported by Research Grant B669 National Institutes of Health United States Public Health Service and by a grant from the American Heart Association. Received for publication Nov. 18 1958. *Present address: Division of Neurology Department of Medicine University of Washington School of Medicine Seattle Wash. ALTERATIONS in pulmonary ventilation and patterns of respiration during sleep have been recognized for many years. Endres1 found an elevation of carbon dioxide tension and DeBruin2 commented on the decrease in respiratory rate noted with sleep. Alterations in patterns of breathing such as Cheyne-Stokes respiration are frequently observed in normal sleeping subjects. More recently Robin and colleagues3 reported a reduction in pulmonary ventilation and altered sensitivity of the respiratory center. These workers used alveo!ar gas tensions as a measure of arterial blood gases. Previous work in our laboratory demonstrated that a retention of carbon dioxide and a slight decrease in arterial oxygen saturation appeared with drowsiness and remained unchanged during deep sleep.4 Ventilatory studies however were not done and the explanation for the alterations in blood gases was speculative. In the present investigation the changes in ventilation during sleep were correlated with the arterial blood pH oxygen saturation and carbon dioxide tension. In addition the ventilatory response to carbon dioxide inhalation during sleep was observed. ... schö

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