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March 2021


Journal/Book: Reprinted from THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE St. Louis Vol. 44 No. 1 Pages 149-159 (1954). 1954;

Abstract: This work was supported by grants from the National Tuberculosis Association and The Squibb Institute for Medical Research. From the Department of Anesthesiology Columbia University College of Physicians and Surgeons and the Anesthesiology Service The Presbyterian Hospital New York 32 N. Y. Received for publication Feb. 10 1954. Cambridge Instrument Co. Research model pH meter No. 11261. RALID fluctuations in the pH of arterial blood occur in response to alterations of effective pulmonary ventilation and attendant changes of CO2 tension.1 2 In the course of a study of ventilation during anesthesia it became necessary to have means for monitoring the pH of blood frequently and conveniently. For this purpose it seemed desirable to have an instrument which would permit direct transfer of blood from the Patient into a glass electrode allow for determination of pH at body temperature and be suitable for use in the presence of explosive gas mixtures in the operating room. No such apparatus is now commercially available. An Instrument which meets these requirements and enables measurements to be made at two-minute intervals with an accuracy of 0.02 pH or better has been devised. . . .

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