Radiat Prot Dosimetry. 2003 ; 104(1): 71-6.

Measurement of 40k as an indicator of body potassium: implication for diabetes and other disease conditions.

Maniyan CG, Mohan G, Pillai PM, Sujata R, Haridasan PP, Khan AH.

Environmental Assessment Division, Bhabha Atomic Research Centre, Health Physics Unit, Indian Rare Earths Ltd, Udyogamandal, Kerala 683 501, India. drmaniyan1@rediffmail.com

Potassium (K) content in 408 male workers of a rare earths processing plant was estimated using a shadow shield whole body counter. The average K content in the non-vegetarian and vegetarian group was found to be 1.5 g kg(-1) and 2.1 g kg(-1) respectively. The absorbed dose due to 40K is determined as 0.18 +/- 0.02 mGy. While the K content was found to be proportional to body build index, it is inversely proportional to slenderness. Body K was maximum in the middle aged group (35-45 y) and a minimum in younger and older persons. The correlation of potassium content with some disease patterns was also studied. Diabetes mellitus patients were observed to have low K content of 0.9 +/- 0.2 g kg(-1) and those who suffer from cardiovascular disorders were found to have high K content 2.7 +/- 0.3 g kg(-1). The studies showed that the depletion of body K content takes place a few years prior to the clinical detection of diabetes and it builds up a few years before the clinical detection of cardiovascular disorders. It is stressed that the medical information is preliminary as the number of subjects studied was not very large. Wider and in depth study by various groups can hopefully strengthen the observation.