Fitoterapia. 2003 Jul; 74(5): 486-8.

Evaluation of analgesic effect of Datura fastuosa leaves and seed extracts.

Abena AA, Miguel LM, Mouanga A, Hondi Assah T, Diatewa M.

Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, University Marien Ngouabi, BP 69, Brazzaville, Congo. abena_cg@yahoo.fr

The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. According to the results, D. fastuosa leaves and seeds extracts at oral doses of 400 and 800 mg/kg are effective as analgesic. The analgesic activity of leaf extract is reduced by naloxone but not that of seed extract.