Phytother Res. 2003 Jun; 17(6): 681-2.

Antiprotozoal activity of the constituents of Rubus coriifolius.

Alanís AD, Calzada F, Cedillo-Rivera R, Meckes M.

Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, 06725, México D F, México.

Extraction of the aerial parts of Rubus coriifolius, a medicinal plant used by the Maya communities in Southern Mexico to treat bloody diarrhoea, resulted in the isolation of seven known compounds (-)-epicatechin, (+)-catechin, hyperin, nigaichigoside F1, beta-sitosterol 3-O-beta-d-glucopyranoside, gallic acid and ellagic acid. All compounds were tested for their antiprotozoal activity against Entamoeba histolytica and Giardia lambia. Epicatechin was the main responsible for the antiprotozoal activity of the extract against both protozoa, its activity was comparable to emetine, but no exceeded that of metronidazole.Copyright 2003 John Wiley & Sons, Ltd.

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