Phytother Res. 2003 Jun; 17(6): 675-7.

Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae).

Okunade AL, Bikoff RE, Casper SJ, Oksman A, Goldberg DE, Lewis WH.

Department of Biology, Washington University in St Louis, MO 63130, USA. Okunade@biology.wostl.edu

Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6alpha-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6alpha-tigloyloxychaparrinone from this species.Copyright 2003 John Wiley & Sons, Ltd.