Fitoterapia. 2003 Jun; 74(4): 350-4.

Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki.

Ryu JH, Ahn H, Jin Lee H.

College of Pharmacy, Sookmyung Women's University, Seoul 140-742, South Korea. ryuha@sdic.sookmyung.ac.kr

The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 microg/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC(50) of 21.6 microM.