Fitoterapia. 2003 Jun; 74(4): 339-44.

Cytotoxic pentacyclic triterpenes from Combretum nigricans.

Simon G, Dewelle J, Nacoulma O, Guissou P, Kiss R, Daloze D, Braekman JC.

Unibioscreen SA, EEBIC, 40 Av. J. Wybran, Brussels 1070, Belgium.

A new pentacyclic triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2). They are responsible, at least in part, for the cytotoxic activity of the methanolic extract of the plant.