Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Apr; 23(4): 275-7.

[Influence of large amount of shengmai injection on blood coagulation in patients with chronic heart failure]

Ma L, Yang L, Chen TD.

Lanzhou Emergency Department Center, Second Affiliated Hospital, Lanzhou Medical College, Lanzhou 730030.

OBJECTIVE: To investigate the effect of Shengmai Injection (SMI) on blood coagulation in patients with chronic heart failure (CHF). METHODS: Sixty patients with CHF were randomly divided into two groups, the 30 patients in the treated group were treated with SMI plus conventional treatment of western medicine, and the 30 in the control group treated with conventional treatment alone. The changes of cardiac function were observed and levels of plasma P-selectin, von Willebrand's factor (vWF) and D-dimer were determined. RESULTS: The total effective rate and the markedly effective rate in the treated group were higher than those in the control group respectively. The levels of P-selectin, vWF and D-dimer lowered in both groups significantly after treatment, but the effect of lowering was better in the treated group than that in the control group. CONCLUSION: Hypercoagulative state exist in patients with chronic heart failure. SMI could improve the state in patients, which may reduce the occurrence and developing of emboic events to certain extent.