Phytother Res. 2003 May; 17(5): 555-7.

Clinical evaluation of Acalypha ointment in the treatment of superficial fungal skin diseases.

Oyelami OA, Onayemi O, Oladimeji FA, Ogundaini AO, Olugbade TA, Onawunmi GO.

Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

In an open non-comparative study to evaluate the efficacy and safety of Acalypha wilkesiana ointment in superficial fungal skin diseases, 32 Nigerian patients with clinical and mycological evidence of superficial mycoses were recruited. Twelve patients defaulted and were lost to follow up, while one patient withdrew because of intolerable excoriation at the site of the lesion. Of the 19 patients that completed the trial, clinical cure was achieved in 73.3% of the patients. The ointment was very efficacious in the treatment of Tinea pedis, Pityriasis versicolor and Candida intetrigo where the cure rate was 100% in each condition. It is recommended that Acalypha ointment can be used for the treatment of these superficial mycoses.Copyright 2003 John Wiley & Sons, Ltd.