Phytother Res. 2003 Apr; 17(4): 341-4.

Antiangiogenic activity of lupeol from Bombax ceiba.

You YJ, Nam NH, Kim Y, Bae KH, Ahn BZ.

College of Pharmacy, Chungnam National University, Taejon 305-764, Korea.

In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.Copyright 2003 John Wiley & Sons, Ltd.