Curr Med Res Opin. 2003 ; 19(1): 59-63.

Psycho-neuro-immunological treatment of hepatocellular carcinoma with major depression--a single case report.

Jozuka H, Jozuka E, Suzuki M, Takeuchi S, Takatsu Y.

Department of Psychiatry, JMC Stress Medical Laboratory and Jozuka Mental Clinic, Nishio, Aichi, Japan. hjozuka@aichi.med.or.jp

A female patient, who was suffering major depression and advanced hepatocellular carcinoma (hepatoma), sought treatment in the Jozuka Mental Clinic. She was treated using a psycho-neuro-immunological approach. The treatments applied were psychotherapy, the antidepressant fluvoxamine, glycyrrhizinic acid and dehydroepiandrosterone (DHEA). Biochemical, endocrinological and immunological examinations were performed regularly. Improvement of liver function and reduction of alpha-fetoprotein were observed. The levels of DHEA, natural killer cell activity and cytokines (interleukines IL-2, IL-6, IL-12, interferon IFN-gamma) were normalised. Now, more than two and a half years after her admission, the patient is still well and symptom-free. While this may be a case of spontaneous regression, the results suggest that a psycho-neuro-immunological approach to treating the patient's depression and cancer was helpful for her recovery.