Yakugaku Zasshi. 2003 Feb; 123(2): 53-62.

[Studies on the marker compounds for standardization of traditional Chinese medicine "polyporus sclerotium ([symbol: see text])"]

Yuan D, Yamamoto K, Bi K, Zhang P, Liu F, Kano Y.

Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, China, Kanebo LTD., Kampo & Healthcare Research Laboratories, 3-1 Kanebo-machi, Takaoka, Japan.

Natural products have been used for healthcare and pharmacotherapy. Because difficulties in quality control affect their production, processing, and marketing, it is necessary to establish adequate marker compounds for their effective application. Ergosta-4,6,8(14),22-tetraen-3-one(I) was studied in the screening of the marker compounds for the standardization of Polyporus Sclerotium ([symbol: see text]), which has the advantage of easy qualitative and quantitative analysis because of its fluorescence. Its applicability in the standardization of Polyporus Sclerotium is discussed based on comparative studies of 30 crude samples of Polyporus Sclerotium and some other fungi herbs using TLC and HPLC analysis with I it as the marker compound, as well as its chemical synthesis.