Phytother Res. 2003 Jan; 17(1): 77-9.

Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation.

Vetrichelvan T, Jegadeesan M.

Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, Tamil Nadu, India. vetrisel@yahoo.com

The antiinflammatory activity of an alcohol extract of Achyranthes aspera was tested on carrageenin-induced hind paw oedema and cotton pellet granuloma models in albino male rats. The paw volume was measured plethysmometrically at 0, 1, 2, 3, 4 and 5 h. In the subacute model cotton pellet granuloma was produced by implantation of 50 +/- 1 mg sterile cotton in the axilla under ether anaesthesia. The animals were fed with an alcohol extract at various dose levels (125, 250, 375 and 500 mg/kg). Diclofenac sodium was used as a standard drug. The alcohol extract (375 and 500 mg/kg) showed the maximum inhibition of oedema of 65.38% and 72.37% at the end of 3 h with carrageenin-induced rat paw oedema, respectively. Using a chronic test, the extract exhibited a 40.03% and 45.32% reduction in granuloma weight.Copyright 2003 John Wiley & Sons, Ltd.