Zhongguo Zhong Yao Za Zhi. 2002 Mar; 27(3): 221-4.

[Effects of epimedium total flavonoids phytosomes on preventing and treating bone-loss of ovariectomized rats]

Jiang YN, Mo HY, Chen JM.

Guangzhou Railway Central Hospital, Guangzhou 510080, Guangdong, China. jyn21967@163.net

OBJECTIVE: To observe the effects of Epimedium total Flavonoids Phytosomes on preventing and treating bone-loss of the castrate osteoporosis rat model. METHOD: The osteoporosis model was established with 4-month-odl panther's rats, their ovaries on both sides castrated. Dual energy X-ray scanning was used to determine the bone density, and immunity and ELASA were used to assay concentration of estradiol and IL-6 in serum respectively, then determine their effect. RESULT: The BMP and E2 of high dosage group nilestriol group and normal group are higher than those of model group (P < 0.01), while their content of IL-6 is apparently lower than that of model group(P < 0.01). CONCLUSION: The osteoporosis model was established successfully and the using of EFP can improve the bone density, enhance E2 level and decrease the IL-6 concentration in serum.