Zhong Yao Cai. 2002 Apr; 25(4): 270-2.

[Apoptotic morphological changes and TUNEL of human gastric cancer cell SGC-7901 induced by aining]

Su M, Dai M, Lü X, Liu J, Li H.

National Engineering Research Center for Mordernization of TCM, Zhuhai 519020.

OBJECTIVE: To investigate the inducing apoptosis effect of Aining on the human gastric cancer cell SGC-7901. METHODS: In vitro cell culture was adopted to explore the inducing apoptosis effect of Aining and cisplation (DDP) through the morphological method and the molecular method. RESULTS: Apoptotic morphological changes were seen after the cells cultured with Aining or DDP; apoptosis rate of 1 g/L Aining group was 46.36%, which had no significant differences with the apoptosis rate 49.12% of the 25 mg/L DDP group; both of the Aining and the DDP groups were significantly different from that of the blank group(P < 0.01). CONCLUSIONS: Both DDP and Aining could induce the apoptosis of human gastric cancer cell and the traditional medicine compound prescription Aining is likely to become a new agent which is used to induce apoptosis of cancer cells.