J Nat Prod. 2002 Dec; 65(12): 1843-7.

Brosimacutins A-I, nine new flavonoids from Brosimum acutifolium.

Takashima J, Ohsaki A.

Research and Development Division, Mitsubishi Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. Takashima.Junko@me.m-pharma.co.jp

Nine new flavonoids, brosimacutins A-I (1-9), and four known flavonoids were isolated from the bark of Brosimum acutifolium, a Brazilian folk medicine ("MururÃ©"). Their structures were elucidated by spectroscopic methods, including 2D NMR. Brosimacutins A-I possess differentially functionalized isoprene units at C-8.