Planta Med. 2002 Nov; 68(11): 1017-9.

Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878.

Pittayakhajonwut P, Theerasilp M, Kongsaeree P, Rungrod A, Tanticharoen M, Thebtaranonth Y.

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Rajdhevee, Bangkok, Thailand. pattamap@biotec.or.th

A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC 50 values of 2.0 and 1.6 microg/mL, respectively.