J Ethnopharmacol. 2002 Nov; 83(1-2): 149-52.

Phenolic antibacterials from Piper betle in the prevention of halitosis.

Ramji N, Ramji N, Iyer R, Chandrasekaran S.

The Procter & Gamble Company, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. ramji.n@pg.com

Piper betle L. (Piperaceae) leaves which are traditionally used in India and China in the prevention of oral malodor was examined by bioassay-guided fractionation to yield allylpyrocatechol (APC) as the major active principle which showed promising activity against obligate oral anaerobes responsible for halitosis. The biological studies with APC indicated that the potential to reduce methylmercaptan and hydrogen sulfide was mainly due to the anti-microbial activity as established using dynamic in vitro models.