Planta Med. 2002 Oct; 68(10): 936-9.

Component of Zingiber officinale that improves the enhancement of small intestinal transport.

Hashimoto K, Satoh K, Murata P, Makino B, Sakakibara I, Kase Y, Ishige A, Higuchi M, Sasaki H.

Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ami-machi, Ibaraki 300-1192, Japan. hashimoto_kazunori@mail.tsumura.co.jp

6-Shogaol, a constituent of Zingiber officinale, improved carbachol-induced accelerated small intestinal transit in vivo, as well as improving longitudinal muscle contraction induced by low-frequency electrical stimulation of the isolated guinea pig small intestine in vitro. In addition, 6-shogaol ameliorated BaCl(2) -induced hyperperistalsis of the small intestine in vivo.