Planta Med. 2002 Sep; 68(9): 850-3.

A new anti-oedematogenic nor-pregnane derivative isolated from Mandevilla illustris.

Niero R, Alves RV, Filho VC, Calixto JB, Hawkes JE, Sant'Ana AE, Yunes RA.

Núcleo de Investigações Químico Farmacêuticas, Curso de Farmácia/CCS, Universidade do Vale do Itajaí, Itajaí, SC, Brazil. neiro@ccs.univali.br

A new nor-pregnane derivative (2,6-dideoxy-3- O-methylpyranosylillustrol) (1), isolated from the ethyl acetate extract of Mandevilla illustris rhizomes, was identified by conventional spectral analysis and by chemical means. It markedly inhibited the rat paw oedema induced by carrageenan and, to a lesser extent, those induced by dextran, without affecting that caused by bradykinin.

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