J Ethnopharmacol. 2002 Oct; 82(2-3): 127-30.

Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae).

Delaporte RH, Sánchez GM, Cuellar AC, Giuliani A, Palazzo de Mello JC.

Instituto Superior de Ciências Farmacêuticas e Bioquímica, Universidade Paranaense, Umuarama, Paraná, Brazil. delaporte@uol.com.br

Anti-inflammatory activity of an ethanolic extract from Bouchea fluminensis leaves was demonstrated. From de ethanolic extract, the active compound was isolated and characterized as the iridoid lamiide. The activity of lamiide on rat-brain phospholipid peroxidation showed a powerful effect (IC(50)=0.92+/-0.01 mM) and an anti-inflammatory activity in carrageenin-induced paw edema test (ED(50)=62.3+/-7 mg/kg weight).

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