Methods Find Exp Clin Pharmacol. 2002 Jul-Aug; 24(6): 357-9.

Studies on the antilithic effect of Rotula aquatica lour in male Wistar rats.

Christina AJ, Priya Mole M, Moorthy P.

Department of Pharmacology, K.M. College of Pharmacology, Tamil Nadu, India. tinatina38@rediffmail.com

The decoction of Rotula aquatica lour was screened for antilithic activity in male Wistar rats and the results were summarized based on the ionic changes in both urine and serum. Nephrolithiasis was induced in rats by feeding them 3% glycolic acid mixed feed for 45 days, which resulted in high urinary calcium, oxalate and high serum potassium. Simultaneous treatment with the decoction reduced calcium and oxalate ion concentration in urine, confirming the stone inhibitory effect. Histopathological studies of kidney tissue samples further substantiated the findings. The decoction was found to be nontoxic over the 45-day treatment period.