Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Feb; 21(2): 102-4.

[Study for effect of kangyanling on cytokine and C-reactive protein in patients of systemic inflammatory reaction syndrome and multi-organ dysfunction syndrome after abdominal surgery]

Chen ZY, Qi QH.

Baodi District Hospital of Tianjin 301800.

OBJECTIVE: To observe the clinical effect and mechanism of Kangyanling (KYL) in treating patients with systemic inflammatory reaction syndrome and multi-organ dysfunction syndrome (SIRS/MODS) after abdominal surgery. METHODS: Eighty-two patients of SIRS/MODS after abdominal surgery were divided into two groups according to admission time, the KYL treated group (n = 35) and the control group (n = 47). The levels of serum C-reactive protein (CRP), plasma tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were measured at the 1st, 3rd and 7th day post-operationally. RESULTS: The levels of CRP, TNF-alpha and IL-6 decreased gradually after surgical operation in both groups, but the reducing velocity was shorter in the KYL group than that in the control group, so the comparison of the levels in the two group showed significant difference on the 3rd day after operation (P < 0.05). CONCLUSION: KYL could inhibit the release of inflammatory mediator and relieve the inflammatory response so as to treat post-operational SIRS/MODS effectively.