Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct; 21(10): 757-9.

[Effect of xiaoyin jiedu yin on Staphylococcus aureus enterotoxin B induced serum interleukin 8 in mice]

Liu M, Qu X, Zhou GF.

Beijing University of TCM, Beijing 100029.

OBJECTIVE: To explore the therapeutic mechanism of Xiaoyin Jiedu Yin (XYJDY) in treating psoriasis. METHODS: Abnormal elevation of interleukin 8 (IL-8) level in mice was induced by Staphylococcus aureus enterotoxin B (SEB), then the antagonizing effects of XYJDY and Composite Qingdai Capsule were observed. RESULTS: Serum IL-8 level arose and reached the peak 3-5 hrs after SEB induction. XYJDY could antagonize the induction significantly, and the effect was more significant when large dosage was given. CONCLUSION: XYJDY, in either large or small dose, could effectively antagonize the SEB induction on IL-8. Applying with superantigen theory, this fact could be used to elucidate the mechanism of XYJDY in removing Heat, cooling blood and detoxifying at cell biologic level.