Biol Pharm Bull. 2001 Dec; 24(12): 1440-2.

Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II.

Konoshima T, Konishi T, Takasaki M, Yamazoe K, Tokuda H.

Kyoto Pharmaceutical University, Japan. konosima@mb.kyoto-phu.ac.jp

Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanovl-phorbol-13-acetate.