J Nat Prod. 2001 Dec; 64(12): 1493-6.

Acutifolins A-F, a new flavan-derived constituent and five new flavans from Brosimum acutifolium.

Takashima J, Ohsaki A.

Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. a-ohsaki.fm@tmd.ac.jp

Acutifolin A (1), a novel constituent with a bicyclo[3.3.1]non-3-ene-2,9-dione ring, acutifolins B-F (2-6), five new flavans, and three known flavans were isolated from the bark of Brosimum acutifolium, a Brazilian folk medicine ("MururÃ©"). Their structures were elucidated by spectroscopic methods, including 2D NMR.