Planta Med. 2001 Dec; 67(9): 873-5.

Antifungal principles from Piper fulvescens.

Freixa B, Vila R, Ferro EA, Adzet T, CaÃ±igueral S.

Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans against five fungi strains were determined. Conocarpan showed the widest activity, whereas eupomatenoid 6 was the most active against dermatophytes.