Planta Med. 2001 Nov; 67(8): 774-6.

Two new sesquiterpene lactones from Montanoa tomentosa ssp. microcephala.

Braca A, Cioffi G, Morelli I, Venturella F, Pizza C, De Tommasi N.

Dipartimento di Chimica Bioorganica e Biofarmacia, Pisa, Italy. braca@farm.unipi.it

Two new sesquiterpene lactones: 8alpha-(4'-acetoxymethacryloyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alpha-olide (1) and 8alpha-(2'E)-(2'-acetoxymethyl-2'-butenoyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alphaolide (2), together with the known zoapatanolide A were isolated from the aerial parts of Montanoa tomentosa Cerv. in La Llave et Lex ssp. microcephala (Sch. Bip. In K. Koch) V.A. Funk (Asteraceae). The structures of all compounds were established on the basis of 1D, 2D NMR, and EIMS analysis.