Ned Tijdschr Geneeskd. 2001 Oct; 145(40): 1943-5.

[Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)]

Güzelcan Y, Scholte WF, Assies J, Becker HE.

Academisch Medisch Centrum, Postbus 22.700, 1100 DE Amsterdam. y.guzelcan@amc.uva.nl

A 23-year-old woman with no psychiatric history developed acute mania and psychosis while using St. John's wort at a high dosage (Valdispert 'balans', a combination of valerian extract and hypericin). She was diagnosed as having substance-induced mood disorder, with manic features (DSM-IV). Discontinuation of the use of the product and treatment with olanzapine led to complete recovery. No causal relationship between the use of the extract and the mania was established, but the course of the mania does suggest this association. St. John's wort is a popular herbal antidepressant. Hyperforin and hypericin, components of St. John's wort, inhibit synaptosomal serotonin, noradrenaline and dopamine uptake. The mechanism of action of St. John's wort is, however, not yet fully understood. St. John's wort should therefore be used with caution, especially in patients with a bipolar disorder.