Eksp Klin Farmakol. 2001 Jul-Aug; 64(4): 56-8.

[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage]

Syrov VN, Khushbaktova ZA.

Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.

Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.