J Ethnopharmacol. 2001 Nov; 78(1): 95-8.

Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice.

Zafar S, Ahmad MA, Siddiqui TA.

Department of Ilmul Advia (Pharmacology), Faculty of Medicine (Unani), Hamdard University, Hamdard Nagar, 110062, New Delhi, India. shadabzafar@rediffmail.com

Chronic treatment with Delphinium denudatum (Dd) (Jadwar) (family: Ranunculaceae, 200-1600 mg/kg) suppressed morphine withdrawal jumps in a dose-dependent manner, a sign of the development of dependence to opiate as assessed by naloxone (2 mg/kg) precipitation withdrawal on day 10 of testing in mice. Repeated administration of Dd (200-1600 mg/kg) for 9 days attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg), also produces significant change in tail-flick latency from the saline pretreated group in a dose-dependent manner.