Hosp Med. 2001 May; 62(5): 274-6.

St John's wort for depression: what's the evidence?

Kelly BD.

Stanley Research Centre Ireland, St John of God Hospital, Stillorgan, Dublin, Ireland.

There is a moderate amount of evidence to suggest that St John's wort is better than placebo in the short-term management of mild to moderate depressive illness, but there is increasing concern over reports of drug interactions. This article examines the scientific evidence and discusses relevant clinical issues.