Presse Med. 2001 Mar; 30(11): 561-4.

[Cancer of the prostate: influence of nutritional factors. A new nutritional approach]

de la Taille A, Katz A, Vacherot F, Saint F, Salomon L, Cicco A, Abbou CC, Chopin DK.

Centre de Recherche chirurgicale, Service d'Urologie, HÃ´pital Henri Mondor, 54, boulevard du MarÃ©chal de Lattre de Tassigny, F94100 CrÃ©teil. ad399@hotmail.com

FIBERS: A group of vegetarian subjects have been shown to have a lower risk of cancer of the prostate than a control group. But the exact role of food fiber remains to be determined because plant foods also have an antioxidant effect on their own. PLANT PRODUCTS AND EXTRACTS: A compound called PD SPEC has been showed to have antitumor effects both in vitro and in vivo. Evaluated in patients with a cancer escaping hormone control, the clinical response was a lower level of prostate specific antigen (PSA). SOYBEANS: Several studies have demonstrated the interesting properties of soybeans. No study has however been able to demonstrate the optimal dose per day. A prospective study is currently under way using a 40 g/day dose. OVERALL NUTRITIONAL APPROACH: Several studies are being conducted using a proposed diet where 15% of the total energy intake comes from fat (associated with a low saturated/unsaturated ratio), high fiber content (18 g/100 kcal) and 40 g daily soybean protein. Although large-scale studies with rigorous methodology are lacking, an overall nutritional approach could be an interesting strategy for the management of cancer of the prostate.