Planta Med. 2001 Mar; 67(2): 164-6.

In vitro activity of a Solanum tuberosum extract against mammary carcinoma cells.

De Lorenzo MS, Lorenzano Menna PL, Alonso DF, Gomez DE.

We investigated the antitumor properties of a Solanum tuberosum extract (STE) on F3II mouse mammary carcinoma cells. STE significantly inhibited adhesion on fibronectin-coated surfaces and blocked migration of tumor cells in vitro. A major gelatinolytic activity (gelatinase) of 82 kD was identified in STE by zymographic analysis and characterized by exposure to different experimental conditions. Proteolytic activity of STE may be responsible, at least in part, for the in vitro effects on mammary carcinoma cells.