Org Lett. 2001 Mar; 3(6): 819-21.

Synthesis of polyacetylenic acids isolated from Heisteria acuminata.

Zeni G, Panatieri RB, Lissner E, Menezes PH, Braga AL, Stefani HA.

Departamento de QuÃmica, LaboratÃ³rio de BioquÃmica ToxicolÃ³gica, UFSM, 97105-900 Santa Maria, RS, Brazil. gzeni@quimica.ufsm.br

Four linear polyacetylenic compounds were synthesized. Pentadeca-6,8,10-triynoic acid 1 and octadeca-8,10,12-triynoic acid 2 were synthesized by using acetylene coupling reactions. The syntheses of (Z)-hexadec-11-en-7,9-diynoic acid 3 and (Z)-octadec-12-en-7,9-diynoic acid 4 by using vinylic telluride coupling reactions were accomplished.