Fitoterapia. 2001 Jan; 72(1): 12-21.

Anthelmintic activity of crude aqueous extract of Nauclea latifolia stem bark against ovine nematodes.

Onyeyili PA, Nwosu CO, Amin JD, Jibike JI.

Department of Veterinary Physiology and Pharmacology, Maiduguri, Nigeria. conwosu@unimaid.edu.ng

The anthelmintic efficacy of Nauclea latifolia stem bark aqueous extract was studied in sheep with natural acute/sub-acute parasitic gastro-enteritis due primarily to mixed nematode species. Graded doses of the extract (400, 800 and 1600 mg/kg, p.o for 5 consecutive days) significantly reduced faecal egg counts in infected animals. The percentage reduction (93.8%) by 1600 mg/kg of the extract was comparable to that of 5 mg/kg of albendazole (94.1%). The administration of the extract resulted in improved haemoglobin and leucocytosis values in worm-infected sheep.