Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Oct; 20(10): 750-2.

[Effect of yimai jiangya extract on plasma neuropeptide Y level in patients of senile hypertension with qi-deficiency and blood stasis syndrome]

Duan X, Yang D, Sun X.

General Hospital of Jinan Military Region, Jinan 250031.

OBJECTIVE: To observe the effect of Yimai Jiangya extract (YMJYE) on plasma neuropeptide Y (NPY) level in patients of senile hypertension at stage II with Qi-Deficiency and blood stasis Syndrome (QDBSS). METHODS: Sixty-eight patients were randomly divided into two groups, 36 patients in the treated group treated with YMJYE and 32 patients in the control group treated with captopine. Radioimmunoassay was used to examine the level of plasma NPY before and after treatment in the two groups. RESULTS: Before treatment, plasma NPY level was significantly higher in both groups than that in the old healthy persons (P < 0.01), it lowered significantly after treatment and the decrement was more obvious in the treated group in comparing with that in the control group (P < 0.01). Blood pressure was significantly lowered in both groups after treatment (P < 0.01) but with no significant difference between them. CONCLUSION: Plasma NPY level was increased in patients of senile hypertension with QDBSS. YMJYE had good effect in lowering plasma NPY level and reducing blood pressure. It is presumed that the NPY lowering effect of YMJYE might be one of its mechanisms in lowering blood pressure.