Phytother Res. 2000 Nov; 14(7): 541-2.

Evaluation of antitussive potential of Jussiaea suffruticosa linn. extract in albino mice.

Murugesan T, Ghosh L, Mukherjee PK, Pal M, Saha BP.

Department of Pharmaceutical Technology, Jadavpur University, Calcutta - 700 032, India.

The antitussive activity of a methanol extract of Jussiaea suffruticosa Linn. (MEJS) (family Onagraceae) leaves has been evaluated for its potential on a cough induced by sulphur dioxide (SO(2)) gas model in mice. The extract (MEJS) showed significant antitussive activity in a dose dependent manner. The antitussive potential of MEJS was comparable to that of codeine phosphate (10 mg/kg), a standard drug. The extract (MEJS) at a dose level of 200 and 400 mg/kg, p.o. showed appreciable inhibition on the cough reflex by 48.52% and 59.8% respectively during 120 min of the experiment.Copyright 2000 John Wiley & Sons, Ltd.