J Ethnopharmacol. 1999 Oct; 67(1): 37-44.

Biological activities of crude plant extracts from Vitex trifolia L. (Verbenaceae).

HernÃ¡ndez MM, Heraso C, Villarreal ML, Vargas-Arispuro I, Aranda E.

Centro de InvestigaciÃ³n en Biotecnologia, UAEM, Cuernavaca, Morelos, Mexico.

Biological assays of Vitex trifolia L. organic extracts have shown relevant activities. Hexanic and dichloromethanic (DCM) extracts, when prepared from stems and foliage, have proved to be very toxic against several cancer cell lines in culture (SQC-1 UISO, OVCAR-5, HCT-15 COLADCAR, and KB). Also, an important antifeeding activity against the insect pest Spodoptera frugiperda (Lepidoptera: Noctuidae) was recorded. The hexanic extract from leaves completely inhibited the growth of the fungal plant pathogen Fusarium sp. within the first 2 days of the experiment, but dropped significantly at day 6 (15% inhibition). The potential of V. trifolia for several uses is discussed.