J Nat Prod. 1999 Oct; 62(10): 1437-8.

A new bisabolene epoxide from Tussilago farfara, and inhibition of nitric oxide synthesis in LPS-activated macrophages.

Ryu JH, Jeong YS, Sohn DH.

College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. ryuha@sdic.sookmyung.ac.kr

A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed inhibition of nitric oxide synthesis in lipopolysaccharide-activated macrophages.