Neurobiological abnormalities in the relatives of schizophrenics

Author(s): Freedman, R.

Journal/Book: J Psychiat Res. 1999; 33: the Boulevard Langford Lane, Kidlington, Oxford Ox5 1GB, England. Pergamon-Elsevier Science Ltd. 491-495.

Abstract: The inheritance of a complex illness such as schizophrenia likely involves the segregation of genetic factors, in combination with non-genetic or environmental abnormalities. This paper reviews several family studies of biological and clinical aspects of schizophrenia, that have attempted to observe such segregation in relationship to family history of schizophrenia to identify which factors appear to be related to the transmission of genetic risk.

Note: Article Waldo MC, Univ Colorado Hlth Sci, Dept Psychiat, Box C268-16 UCHSC, 4200 E 9th Ave, Denver,CO 80262 USA

Keyword(s): sensory gating; schizophrenia; SPEM; auditory evoked potential; genetics; EYE-MOVEMENT DYSFUNCTIONS; FATTY-ACID COMPOSITION; SMOOTH-PURSUIT; NEUROPHYSIOLOGICAL EVIDENCE; FAMILIAL TRANSMISSION; TRACKING DYSFUNCTION; BIOLOGICAL RELATIVES; MONOZYGOTIC TWINS; P50 SUPPRESSION; PLASMA

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