Blood pressure and heart rate rhythmicity: Differential effects of late pregnancy

Author(s): Penev, P. D., Peneva, A. V., Cornelissen, G., Halberg, F., Ikonomov, O. C.

Journal/Book: Physiol Behav. 1999; 66: the Boulevard Langford Lane, Kidlington, Oxford Ox5 1GB, England. Pergamon-Elsevier Science Ltd. 269-275.

Abstract: Arterial blood pressure (BP) and heart rate (HR) of 31 hospitalized pregnant women at low risk of hypertension were automatically monitored for 48 h at 15-min intervals. Each of the recorded 56 data series for systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and HR was chronobiologically assessed by linear-nonlinear rhythmometry. The rhythm-adjusted mean (MESOR), circadian amplitude, circadian acrophase, and best-fitting period were grouped by pregnancy trimester and further subjected to analysis of variance. BP MESOR remained unaltered, whereas HR MESOR increased significantly in middle and late pregnancy. Ultradian rhythms, with an amplitude higher than that of the circadian rhythm, were found in 25% of the SAP records in the second and third trimester. Such ultradian rhythms were not detected in the simultaneously recorded HR. Finally, the group BP and HR circadian acrophases coincided in the first trimester, but were significantly apart in mid and late pregnancy. These observations support the notion that the coordination of BP and HR rhythmicity involves different physiological mechanisms. Analysis of the individual variability in the chronobiological end points (based on the records of nine women monitored in each pregnancy trimester)revealed that only the BP MESOR was well reproducible in the course of pregnancy and may be useful in early diagnosis of gestational hypertension.

Note: Article Ikonomov OC, Wayne State Univ, Sch Med, Dept Psychiat, 2309 Scott Hall, 540 E Canfield, Detroit,MI 48201 USA

Keyword(s): circadian rhythm; ultradian rhythm; chronobiological assessment; blood pressure; heart rate; pregnancy; CIRCADIAN-RHYTHMS; GESTATIONAL HYPERTENSION; CHRONOBIOLOGY; PREECLAMPSIA; VARIABILITY; TRIMESTER

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