Visual P300 in treatment-resistant schizophrenic patients

Author(s): Milovan, D. L., Baribeau, J., Stip, E.

Journal/Book: Brain Cognition. 1999; 40: 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. Academic Press Inc. 247-251.

Abstract: Although cognitive functioning in schizophrenia continues to be the focus of considerable research, few studies have attempted to evaluate the cognitive functions of neuroleptic treatment-resistant schizophrenic patients. Reduced amplitude of the P300 event-related potential (ERP) is one of the most consistently reported cognitive abnormality in schizophrenia. We therefore sought to determine whether treatment-resistant schizophrenic patients are also characterized by a significant reduction in P300 amplitude, Subjects responded to an infrequent visual stimulus while ignoring binaurally presented auditory stimuli. No group differences were observed for reaction time or P300 amplitude. The percentage of correct responses was excellent for all subjects, although controls were more accurate.

Note: Article Roth RM, Concordia Univ, Lab Human Neurophysiol & Neuropsychol, Montreal, PQ, CANADA

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