Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

Author(s): Wilson, W. H., Chiu, N. Y., Turkington, T. G., Degrado, T. R., Coleman, R. E.

Journal/Book: Acta Psychiat Scand. 1999; 100: 35 Norre Sogade, PO Box 2148, Dk-1016 Copenhagen, Denmark. Munksgaard Int Publ Ltd. 67-75.

Abstract: Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

Note: Article Mathew RJ, Duke Univ, Med Ctr, Dept Psychiat, Box 3972, Durham,NC 27710 USA

Keyword(s): depersonalization; tetrahydrocannabinol (THC); positron emission tomography (PET); cerebral blood flow (CBF); OBSESSIVE-COMPULSIVE DISORDER; QUANTITATIVE MEASUREMENT; SCREENING-TEST; MARIJUANA USE; FRONTAL LOBE; BRAIN; AGORAPHOBIA; METABOLISM; TOMOGRAPHY; ACCURACY

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