Hemispheric-synchronisation during anaesthesia: a double-blind randomised trial using audiotapes for intra-operative nociception control

Author(s): Ruta, D., Ogston, S., Landeck, A., Martay, K.

Journal/Book: Anaesthesia. 1999; 54: 769-73.

Abstract: The possible antinociceptive effect of hemispheric-synchronised sounds, classical music and blank tape were investigated in patients undergoing surgery under general anaesthesia. The study was performed on 76 patients, ASA 1 or 2, aged 18-75 years using a double-blind randomised design. Each of the three tapes was allocated to the patients according to a computer-generated random number table. General anaesthesia was standardised and consisted of propofol, nitrous oxide 66%/oxygen 33%, isoflurane and fentanyl. Patients breathed spontaneously through a laryngeal mask and the end-tidal isoflurane concentration was maintained near to its minimum alveolar concentration value of 1.2%. Fentanyl was given intravenously sufficient to keep the intra-operative heart rate and arterial blood pressure within 20% of pre-operative baseline values and the fentanyl requirements were used as a measure of nociception control. Patients to whom hemispheric-synchronised sounds were played under general anaesthesia required significantly less fentanyl compared with patients listening to classical music or blank tape (mean values: 28 microgram, 124 microgram and 126 &mgr;g, respectively) (p 0.001). This difference remained significant when regression analysis was used to control for the effects of age and sex.

Keyword(s): Acoustic Stimulation/methods. Adolescence. Adult. Aged. Analgesia/methods. Anesthesia, General. Anesthetics, Intravenous/administration & dosage. Awareness. Cortical Synchronization. Double-Blind Method. Drug Administration Schedule. Female. Fentanyl/administration & dosage. Human. Intraoperative Care/methods. Male. Middle Age. Music

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